Program of CLEPIC 2022

Day 1

08.06.2022

Conference Hall Rybacka 1, Szczecin

10:00 AM - 1 PM

Registration

12:00 - 1:00 PM

Light lunch offered (3rd Floor)

1:00 - 2:00 PM

1:00 - 1:15 PM

1:15 - 2:00 PM

Opening

  • Welcome by the Organizers and Editors-in-Chief of Clinical Epigenetics and Epigenetics Communications: Marianne Rots and Lucia Altucci

  • Opening Keynote by Susan Clark: The Cancer Epigenome

2:00 - 3:45 PM

2:00 - 2:30 PM

2:30 - 3:00 PM

3:00 - 3:30 PM

3:30 - 3:45 PM

Session 1: Epigenetic Mechanisms

  • Albert Jeltsch: Investigation of the specificity and mechanism of DNA modifying enzymes by Deep Enzymology approaches

  • Angel de Lera: ​Adventures and nightmares: total synthesis of nahuoic acid, a SAM-competitive inhibitor of SETD8

  • Henk Stunnenberg: Systemic inflammation impairs interferon type I signalling and myeloid lineage development

  • Katarzyna Łagosz-Ćwik: Identification of key DNA methylation-sensitive cellular processes in gingival fibroblasts using the DNMT inhibitor decitabine: implications for periodontitis pathogenesis

Chaired by: Marianne Rots and Maria Berdasco

3:45 - 4:15 PM

Coffee break (1st Floor)

4:15 - 6:30 PM

4:15 - 4:45 PM

4:45 - 5:15 PM

5:15 - 5:45 PM

5:45 - 6:15 PM

Session 2: Epigenetics of disease

  • Charlotte Ling: Epigenetic modifications impact type 2 diabetes and may be used for precision medicine

  • Paola Arimondo: DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness.

  • Harold Snieder: DNA Methylation in Prevalent and Incident Type 2 Diabetes

  • Moshe Szyf: Deconvoluting the functional role of DNA methylation using CRISPR-mediated steric hindrance; implications for epigenetic therapy and prospects for epi-gene therapy

Chaired by: Lucia Altucci and Angel de Lera

  • Claudia Theys: Elucidation of epigenetic interplay of PPAR-alpha and mitochondrial metabolic functions in non-alcoholic fatty liver disease

6:15 - 6:30 PM

6:30 - 9:00 PM

Poster session and welcome finger food
at the conference area (3rd Floor)

Sponsored talk in Sponsors Meetings Auditorium BGI

Day 2

09.06.2022

Conference Hall Rybacka 1, Szczecin

9:00 - 10:45 AM

9:00 - 9:30 AM

9:30 - 10:00 AM

10:00 - 10:30 AM

Session 3: Epigenetic Biomarkers

  • Maria Berdasco: Some shorts stories to consider in epigenetic biomarker discovery

  • Bożena Kamińska: Mapping chromatin accessibility and active regulatory elements in human gliomas reveals pathological mechanisms, new targets and biomarkers

  • Tomasz K Wojdacz: Epigenetic biomarkers and causal methylation changes in blood cells during SARS-CoV-2 infection

Chaired by: Harold Snieder and Pamela Munster

11:15 AM - 1:15 PM

11:15 - 11:45 AM

11:45 - 12:15 PM

12:15 - 12:45 PM

12:45 - 1:00 PM

Session 4: Cancer Epigenetics

  • Carmen Jeronimo: Uncovering the role of the epigenetically-regulated miR-30a/c-5p in renal cancer: from biology to the biomarker potential

  • Monika Hegi: Leveraging epigenetic vulnerabilities in glioma, biomarkers and drugable targets

  • Pamela Munster: Epigenetic modulation of PARP inhibitors in patients with HRD mutations

  • Olga Taryma-Leśniak: Long-term treatment with bortezomib induces specific methylation changes in neuronal cells

Chaired by: Bożena Kamińska-Kaczmarek and Paola Arimondo

10:45 - 11:15 AM

Coffee break (1st Floor)

2:15 AM - 3:45 PM

2:15 - 2:45 PM

2:45 - 3:15 PM

3:15 - 3:45 PM

Session 5: Epigenomic approaches
across the tree of life

  • Ryszard Maleszkal: "Nothing in [Epigenetics] Makes Sense Except in the Light of Evolution”

  • Frank Johannes: Spontaneous epimutations in plants

  • Isabel Bäurle: Adaptation to environmental stress by a chromatin-based stress memory

Chaired by: Albert Jeltsch and Joost HA Martens

1:15 - 2:15 PM

Lunch break (3rd Floor)

3:45 - 4:15 PM

Coffee break (1st Floor)

4:15 - 6:00 PM

4:15 - 4:45 PM

4:45 - 5:15 PM

5:15 - 5:45 PM

Session 6: Computational analysis of epigenomes

  • Simon Heath: Computational and statistical analysis of whole genome and epigenome profiles from EM-Seq on liquid biopsies

  • Joost HA Martens: Cis-regulatory elements-based transcription factor prediction using 5’-end capped RNA

  • Andrew E Teschendorff: Tackling the cell-type heterogeneity challenge in epigenome studies

Chaired by: Henk Stunnenberg and Frank Johannes

  • Anne Bozack: Prenatal essential and non-essential metal mixtures and differentially methylated regions in cord blood: application of AclustsCCA, a novel mixture method for epigenome-wide studies

5:45 - 6:00 PM

  • Joanna Borkowska: 5hmC profile as epigenetic marker differentiating adipose tissue-derived mesenchymal stromal cells from dermal fibroblasts

10:30 - 10:45 AM

  • Sponsored talk  in Sponsors Meetings Auditorium
    1st floor: Illumina

  • Sponsored talk in Lecture Hall
    ground floor: MethylDetect ApS

6:15 - 7:00 PM

Keynote speech by Stephan Beck: Connecting Dots for (Epi)Genomic Medicine

  • Federica Sarno: Integrated biological and chemical epigenetic-targeting platform to improve cancer therapy

1:00 - 1:15 PM

Chaired by: Tomasz Wojdacz

8:00 - 11:00 PM

Conference dinner
at Pomeranian Dukes' Castle in Szczecin

Day 3

10.06.2022

Conference Hall Rybacka 1, Szczecin

9:00 - 10:45 AM

9:00 - 9:30 AM

9:30 - 10:00 AM

10:00 - 10:30 AM

10:30 - 10:45 AM

Session 7: Development and Ageing

  • Alex Meissner: Mechanisms of epigenetic regulation in development and disease

  • Riccardo Marioni: Updating and improving epigenetic predictors of chronological and biological age

  • Wolfgang Wagner: DNA methylation changes in aging and senescence

  • Renata Jurkowska: High-resolution transcriptomic and epigenetic profiling across disease stages identifies novel regulators of COPD

Chaired by: Monika Puzianowska-Kuźnicka and Wolfgang Wagner

10:45 - 11:15 AM

Coffee break (1st Floor)

11:15 - 12:00 PM

Closing Keynote by Wolf Reik: Epigenetic regulation in development and ageing

Chaired by: Renata Jurkowska

12:00 - 12:30 PM

Awards and closing ceremony

12:30 - 1:30 PM

Lunch or pick up lunch break (3rd Floor)

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Session topics

Epigenetic Mechanisms

Cause versus consequence, order of events, context-specificity: although increasing insights have been obtained in epigenetic mechanisms the last decade, recent technologies unveil a high complexity with respect to mechanisms. This session will discuss some recent developments in our understanding.

Epigenetics of disease

Epigenome-wide association as well as focussed studies have pinpointed epigenetic dysregulations as major factors in various pathophysiologies. This session will discuss some recent insights and how these can be translated to benefit patients,

Development and Ageing

Already before the start of life, epigenetic reprogramming is essential is controlling and maintaining cell identity. As we grow old, these mechanisms might go wrong associating epigenetics with healthy ageing and in the future maybe with rejuvenation.

Cancer Epigenetics

Most knowledge on epigenetic dysregulation is achieved in oncology with clinical drugs being approved. This session will focus on current advances in cancer epigenetics.

Epigenomic approaches across the tree of life

To stimulate cross-fertilisation between epigenetic insights in all kingdoms of life, this session provides a platform to exchange knowledge and explore model systems.

Talks selected from Abstracts

Talks in this session will offer a platform for young scientist to showcase their work and will future research selected from submitted abstracts.

Computational analysis of epigenomes

With the rapid developments in omics data analyses this session will address main trends in bioinformatics analysis in epigenetic studies.

Epigenetic Biomarkers

Epigenetics biomarkers have a chance to significantly impact personalized medicine. This session will focus on the translation aspect of the epigenetic biomarkers research, especially in liquid biopsies applications.

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